What is fetal growth restriction (FGR)?

Fetal Growth Restriction happens when a baby does not grow in the womb as expected. The most common reason is a  placenta that does not give enough nutrients and oxygen to the baby. This can cause serious health problems, especially if it starts early in the pregnancy.

What is the function of the placenta?

In the placenta, the blood of the mother and the baby flows very close togheter. This allows nutrients and oxygen to go to the baby and waste products to go to the mother. If the placenta does not werk well, the baby cannot grow properly and gets low oxygen levels.

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What is normal fetal growth?

Each baby growths in its own way.  There is natural variation, especially in the later phases of pregnancy. Around 20 weeks of pregnancy, the average baby weighs about 300 grams, increasing to about 1200 by 28 weeks and about 1900 grams at 32 weeks. In these 4 weeks only, babies grow nearly 60% on average! After 32 weeks, the growth rate slows down, also in normal pregnancy.

We often compare your baby’s growth to normal values. This means we look at the baby’s measurements and compare them to those of other babies at the same gestational age of pregnancy. We use percentiles to explain this and is often displayed in the reference growth curve. For example, a baby at the 40th percentile (p40) means that approximately 40% of babies at that gestational age are smaller, and 60% are larger. If the baby is around the same percentile in later measurements, it is likely normal.

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One way to measure the baby’s size is by feeling the height of the uterus through the abdomen. If this seems suboptimal, challenging to feel due to the mother’s weight, or if there’s an increased risk of FGR, a growth ultrasound is typically recommended. During this ultrasound, various measurements of the head, abdomen, and legs are taken and combined to estimate the weight of the baby (called estimated fetal weight). It is important to note that these measurements are not extremely precise, so that this number is interpreted as an estimation rather than a scale weight. Also, with one measurement we know the baby’s size, with repeated ultrasound measurements we have an estimation of the growth. In order to assess the baby’s growth, it is best to leave ample time between measurements to account for the uncertainties of ultrasound measurements.

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How to find a baby with abnormal growth?

To check if the growth of the baby is too slowly, we compare the baby’s size to normal values, as described in the previous question. The challenge is to find the baby who is not growing well because the placenta is not working properly. This is more likely at the lowest percentiles. Another clue is a drop in the percentiles in serial measurements. We also look for abnormalities in the blood flow in the baby’s umbilical cord and brain, or in the mother’s blood vessels that supply the womb.

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Blood vessels are assessed with Doppler ultrasound. It shows the blood flow velocity patterns and the measurements we take reflect the resistance of the organs that the blood flows towards.

The blood vessels that are most often measured are:

  • Arteria uterina (uterine artery): the blood vessel of the mother that supplies blood to the womb. An abnormal measurement can indicate that indeed the placental development has not been optimal.
  • Arteria umbilicalis (umbilical artery): the artery in the umbilical cord.  An abnormal measurement may suggest high resistance in the placenta, which may be simplified as ‘the placenta is too small for this baby’. Because the placenta does not let enough blood through, the baby’s heart has to work harder. This measurement therefore reflects the increased effort from the heart of the baby.
  • Arteria cerebri media (middle cerebral artery): this is an important blood vessel in the brain of the baby. If the placenta does not work well, the baby redistributes blood preferentially towards the most important organs (the brain and the heart). This is good because it helps the important organs, but it’s also not good because it means there’s a problem.
  • Ductus venosus: this is the blood vessel that transports the oxygen-rich blood from the placenta back to the heart of the baby. When the baby’s heart is struggling to perform the increased effort and starts to fail, this may be seen here.

What can be the cause of a small baby?

A baby is called small if the baby is within the smallest 10 percent of babies. If a baby is small, it may be just naturally small, or there could be another reason. The placenta might not be working well, or it could be due to a syndrome, a virus, a disease in the mother, smoking, anemia or poor nutrition.

Diagnosing is not always easy and your doctor will look at all these possibilities and decide which one is most likely. When your doctor looks at all the options, there is usually no single tool that gives a clear answer right away. Instead, doctors look at patterns to recognize by checking all signs and symptoms together. Each situation needs a special approach.

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Causes of smallness can be:

  • Constitutionally small: among all small babies (the smallest 10 percent), this is the most common reason. But it is ultimately the likely diagnosis only after excluding other causes.
  • Placenta: mostly indicated if the blood flow between the mother and baby is abnormal or if the baby’s growth trajectory is abnormal.
  • Syndrome-related anomaly: if the baby is small for gestational age, this should also be considered. Tests to assess this are an anomaly scan (20-week ultrasound), non-invasive prenatal testing (NIPT) or amniocentesis.
  • Viral illnesses: some viruses, like cytomegalovirus or parvovirus, can cause abnormal growth. Recent infections can be tested in the mother’s blood, especially if there are signs of echogenic bowel or calcifications in the brain.
  • Maternal disease: some diseases in the mother can affect blood flow to the womb.
  • Smoking: if a pregnant woman smokes, it can cause low oxygen levels for the baby.
  • Anemia: severe and prolonged anemia can affect the transport of oxygen to the womb.
  • Malnourishment: if a pregnant woman has severe dietary deficiencies, it can affect the baby’s growth.

Why is it important to find FGR early?

Diagnosing FGR early is very important. If the placenta does not work well, it can cause health problems for the baby and sometimes also for the mother. Signs of FGR are the baby being too small and abnormal blood flow in the baby and the mother. These signs can show low oxygen levels, which can be very dangerous for the baby if birth is not done quickly.

What does FGR mean for the baby?

Please remember that every situation is different and has its own approach and outcomes. In general, there are risks related to this serious complication of pregnancy, depending on how severe the signs and symptoms are. Before birth, FGR may lead to stillbirth if the oxygen problem gets worse. If the baby is at an acceptable gestational age and estimated weight, doctors will monitor its condition and attempt to prevent stillbirth by timely delivery. This usually happens through a caesarean section (c-section) if signs of the baby’s health worsening are seen during monitoring. After birth, problems can affect the lungs, bowels, blood, and brain, and sometimes can be life-threatening.

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Several factors are very important for understanding the risks:

  • The gestational age at birth is key. The further along the pregnancy is at birth, the better the chances of avoiding serious complications. This is the most important factor.
  • How severely stunted the baby’s growth is The more the growth is affected, the higher the risk of problems after birth.
  • The baby’s condition at birth. If the baby, in addition to being too young and too small, also has a serious oxygen problem around birth, this can lead to serious complications.

After birth, the baby needs help with many body functions. That’s why the baby must stay in an incubator until the baby is old and big enough. This usually takes several weeks to months. We often recommend that the baby stays in the hospital until the due date if everything goes well. It is also important to check the baby’s development over time, so the baby should come back to the hospital regularly.

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